Catalogue of project tools
In order to help scientists outside of our projects in their research efforts, we have started building a catalogue of accessible tools generated by our projects. Please keep in mind that this list is not comprehensive.
If you know of a tool which should be included in this catalogue please contact us.
Project acronym | Resource | Short description | Link or contact | Access conditions | |
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EU-Pearl | Glossary of terms for complex trials, and platform trials | The document includes key terms that range from comprehensive definitions of master protocol elements and its different types, to statistical terminology or biomarkers terms as well as other relevant information on platform trials approach | link | Free | |
GetReal | Real-World Evidence Navigator |
An online resource designed to help users from a broad range of research and healthcare backgrounds get to grips with Real World Evidence (RWE). RWE refers to evidence of relative effectiveness - how well medicines work in the real world, as opposed to the controlled experimental settings of clinical trials.
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link | Free | |
EMIF | EMIF Data Catalogue |
This online catalogue includes population-based data sources (e.g. electronic health records, regional databases) and cohorts (mainly in the Alzheimer’s field) where the EMIF project partners have consented to providing information to bona fide researchers who want to explore potential data partners for their own work.
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link | Free | |
GetReal/GetReal initiative | GetReal Trial Tool |
Innovative tool to evaluate the options and implications of introducing real world evidence in clinical trial design.
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link | Free | |
CHEM21 | CHEM21 online learning platform |
This platform comprises a range of free, shareable, and interactive educational and training materials created to promote the uptake of green and sustainable methodologies, with a particular focus on the synthesis of pharmaceuticals.
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link | Free | |
EUPATI | Guidance documents on patient involvement in R&D |
Guidance documents on patient involvement
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link | Free | |
EUPATI | EUPATI toolbox |
A toolbox on medicines research and development for patients or patient advocates interested in learning more and engaging in the process
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link | Free | |
EUPATI | Training courses |
EUPATI offers face-to-face and online courses on medicines’ research & development and patient engagement, and can also provide training tailored to an organisation's specific needs.
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link | Free | |
ULTRA-DD | Priority index tool for target discovery |
A genomic-led target prioritisation system, with the focus on leveraging human genetic data to prioritise potential drug targets at the gene, pathway and network level
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link | Free | |
ULTRA-DD | Chemical probes |
Chemical probes for drug discovery applications
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link | Free | |
ULTRA-DD | Protein structure catalogue |
Protein structure catalogue
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link | Free | |
ULTRA-DD | Antibodies catalogue |
Antibodies catalogue
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link | Free | |
ULTRA-DD | Chromochub |
A resource tool to disseminate information regarding the gene specific reagents that have been generated and are available to apply in drug discovery efforts
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link | Free | |
AETIONOMY | AETIONOMY knowledge base |
The most comprehensive knowledge base on Alzheimer's and Parkison's disease worldwide
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link | Free | |
EBiSC | EBiSC catalogue |
Catalogue of human iPS cells being made available to academic and commercial researchers for use in disease modelling and other forms of preclinical research
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link | Free | |
eTOX |
eTOXsys |
Predictive toxicology models and database of animal toxicity studies. | link | Sampler for free | |
IMIDIA | ß-Cell & Diabetes Platform BCDP |
The BCDP captures the ß-cell information and results from the IMIDIA consortium and is a knowledge platform integrating clinical, transcriptomics, lipidomics and genetics (GWAS) data from human and mouse islet samples. The platform was assembled during the IMIDIA project and currently contains clinical information from 500 human individuals both with and without type 2 diabetes (T2D). Approximately half of the patient samples are from organ donors (heart beating) and half are from partially pancreatectomized patients. Islet transcriptomics and genetics (GWAS) data are available for a large subset (~300) of these patients. The platform also contains a large set of mouse islet transcriptomics, plasma lipidomics and multiple phenotypic measurement data from 6 strains of metabolically challenged mice (>1300 mice) whose diabetic phenotype was followed over time (2, 10, 30 and 90 days). Web tools are available to explore differential expression results, gene co-expression modules, correlations of genes and lipids to clinical and phenotypic traits and cross querying of human and mouse data.
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By application based on specific conditions | ||
IMIDIA | Human ß cell lines |
Several variations of human beta cell lines commercially available. Those cell lines express insulin and have a phenotype and function close to the primary adult human beta cells and represent a unique tool to further study beta cell function.
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link | Commercially available | |
Quic-ConCePT | Imaging biomarker roadmap |
Imaging biomarker (IBM) roadmap with key 14 recommendations for clinical translation of IBM
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link | Publication fee | |
PREFER |
Glossary of terms |
Glossary providing working definitions for a number of terms relevant to patient preferences. This is a living document used in the project to facilitate the interactions among researchers |
link | Free | |
PROTECT | Adverse Drug Reactions Database |
The PROTECT ADR database is a downloadable Excel file listing all of MedDRA Preferred Terms (PT) or Low Level Terms (LLTs) adverse drug reactions (ADRs). It is a structured Excel database of all adverse drug reactions (ADRs) listed in section 4.8 of the Summary of Product Characteristics (SPC) of medicinal products authorised in the EU according to the centralised procedure.
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link | Free | |
PROTECT | Benefit-risk assessment website |
The goal of the PROTECT project is to strengthen the monitoring of the benefit-risk balance of medicines in Europe and to enhance early detection and assessment of adverse drug reactions from different data sources. This user-friendly interface includes practical recommendations for benefit-risk decision processes, and supporting tools, methodologies, visualisation and case studies.
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link | Free | |
PROTECT | Drug Consumption Databases in Europe |
The inventory of Drug Consumption Databases in Europe is a comprehensive and structured source of information on drug consumption in Europe. It comprises two documents. The master document contains a detailed report of the available information, methods to retrieve this information, a description of the validity of national drug consumption data and a discussion. The country profile document summarizes the main results by country.
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link | Free | |
PROTECT | PROTECT recommendations on Good Signal Detection Practices |
Actionable advice to pharmacovigilance professionals to improve signal detection practices, whether in a national or international agency or in a pharmaceutical company setting.
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link | Free | |
PRO-active | Conceptual framework on physical activity |
Guidance on the development and content validation of two patient reported outcome (PRO) instruments on physical activity that could be used as a model for other diseases.
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link | Free | |
GetReal | Aggregate Data Drug Information System (ADDIS) |
Aggregate Data Drug Information System (ADDIS) is a data management and analytical tool for evidence based decision making in healthcare (a tool for conducting (network) meta-analyses and benefit-risk analyses).
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link | Free | |
GetReal | Sure-Real Software |
An interactive simulation modelling tool for assessing the impact of implementing alternative evidence generation strategies in clinical drug development, using real-world evidence.
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link | Software licence contained in the end-user license agreement | |
GetReal | Real-World Evidence in Medicine Development Course |
An interactive online course that gives an understanding of current techniques, opportunities and challenges for the use of real-world evidence in medicine development
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link | Fee to enrol in the course | |
GetReal | Glossary of Definitions of Common Terms |
GetReal aims to develop new approaches for incorporating real life data into drug development. This glossary contains definitions of key terms, both for the purpose of GetReal, and also with the aim of providing clarity to external stakeholders around these terms.
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link | Free | |
GetReal | Review of current policies/perspectives on using Real World Data |
Review of different stakeholders’ policies and perspectives on using Real World Data (RWD) for early drug development and clinical effectiveness assessment. It assesses the policies on RWD use, the context within which RWD is/ could be used, and the perspectives of stakeholders on the advantages, disadvantages and obstacles encountered when collecting and using RWD.
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link | Free | |
U-BIOPRED | A short guide to successful patient involvement in EU-funded research |
A short guide to successful patient involvement in EU-funded research. Available in 10 languages.
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link | Free | |
ADAPT-SMART | Glossary of definitions of common terms |
ADAPT SMART aims to create a platform where the conditions and feasibility of medicines adaptive pathways to patients (MAPPs) implementation within the EU regulatory/legal context can be discussed openly. This glossary provides working definitions for common terms relevant for the consortium and includes references.
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link | Free | |
BioVacSafe | tmod: Module enrichment tool |
A new approach to gene module enrichment, which allows highly specific analysis of transcriptional modules in immune related analyses. This is coupled with novel approaches in visualization of gene module enrichments, especially for serial analysis e.g. of time series in immunization.
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link | The tool is distributed with the GPL (GNU public license) |
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BTCure | Credible Refinement and Annotation of Functional Target |
Credible Refinement and Annotation of Functional Targets (CRAFT) is a pipeline for the calculation, annotation and visualisation of credible SNP sets. The aim is to prioritise genetic variants for functional follow-up by refining each association signal to a subset of SNPs with further prioritisation achieved by mapping to experimentally derived functional genomic data, for example chromatin segmentation states. The pipeline exploits publically available data from Ensembl, the Roadmap Epigenomics Project and Blueprint.
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link | Free | |
U-BIOPRED | Human Experimental Exacerbation Study - Rhinovirus (RV16) for use in human viral challenge studies |
A good manufacturing practices rhinovirus was produced as tested as a model of exacerbation in a human viral challenge study. The virus is IMPD and ready for use in clinical trials. All necessary stability and saftey tests have been carried out sucessfully and the virus has also proven to be effective. A full Rhinvirus challenge trial protocol and IMPD documentation (with some partner specific confidential content redacted) will be shared when purchasing the RV16UB virus.
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An access request form can be obtained from BioSci Consulting: link | Due to the very considerable ongoing costs of maintaining and storing the virus a significant cost is levied, based on the number of vials requested. This cost is however very small compared to the cost of producing an IMPD virus - which also comes with the risk that the produced virus is not effective. Costs begin at €20,000. | |
U-BIOPRED | Adult and paediatric cohorts of patients with asthma. Biobank of 50,000 samples |
Baseline and longitudinal data available on 1025 patients/controls in 8 cohorts. Quality biobank created with 50,000+ samples (blood, sputum, lung tissue, urine) linked to clinical data. Data is hosted at Imperial College London. The biobank is maintained in Manchester/Salford. All requests must follow a procedure and require Scientific Board approval.
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Contact the cosortium: link | A charge for external requests for samples will be levied against the costs of management and processing. No charge has been made to date for data requests. Policies are reviewed annually. | |
U-BIOPRED | Diagnosis and definition of severe refractory asthma: an international consensus statement |
Consensus statement on severe asthma definition and the clinical algorithm to confirm the diagnosis of true severe asthma among patients with clinically ''difficult'' asthma.
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link | Free | |
U-BIOPRED | Fingerprints and proof of concept for use of an integrative ‘handprint’ as a means of stratifying asthma populations based on endotypes |
Sets of phenotypes/endotypes based on clusters for each 'omics technology'.
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link link link link link |
Related data free as listed. DAPs may also be shared on request. | |
U-BIOPRED | Standard operating procedures and protocol for adult and paediatric observational clinical trials |
A full set of 100+ standard operating procedures and protocol related-documents which can be shared with researchers upon signature of a standard memorandum of understanding
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Free of charge | |
eTOX | eTOXlab | Flexible modelling framework, developed for supporting models predicting the biological properties of chemical compounds in production environments. | link | Free (GNU GPL version 3) | |
eTOX | Preclinical ontologies |
Hpath is an ontology of histopathology terms used to describe observations made during mandatory animal studies conducted before first human testing. It was created based on existing scientific glossaries and complemented to cover the needs of the eTOX project. It was deposited in the public domain with the ambition to create a new common resource for the community. |
link | Free | |
eTOX | OntoBrowser |
The OntoBrowser tool was developed to manage ontologies and code lists. The primary goal of the tool is to provide an online collaborative solution for expert curators to map code list terms (sourced from multiple systems/databases) to preferred ontology terms. Other key features include visualisation of ontologies in hierarchical/graph format, advanced search capabilities, peer review/approval workflow and web service access to data. |
link | Free | |
EHR4CR |
EHR4CR platform |
Open IT platform that unlocks the information stored in Electronic Health Records for improving clinical research while fully respecting patient privacy and ensuring a high level of security. |
Contact the consortium | Free | |
Open PHACTS | Open PHACTS Discovery Platform |
Single platform linking many drug discovery data sources together so that users can easily see the relationships between compounds, targets, pathways, diseases and tissues. Data sources include ChEBI, ChEMBL, SureChEMBL, ChemSpider, ConceptWiki, DisGeNET, DrugBank, Gene Ontology, neXtProt, UniProt and WikiPathways. |
link | Subscription | |
CHEM21 | Massive Open Online Course in industrial biotechnology |
Covers the key enabling technologies that underpin biotechnology research including enzyme discovery and engineering, systems and synthetic biology and biochemical and process engineering. |
link | Free | |
eTRIKS |
eTRIKS data catalogue |
Catalogue of translational data from eTRIKS and other translation research projects. | link | Free | |
eTRIKS | eTRIKS Labs | Platforms, services, and guidance for the use and re-use of translational research data. | link | Free | |
eTRIKS | eTRIKS Code of Practice |
Code of practice on secondary use of medical data in scientific research projects. |
link | Free | |
ELF | HTS Screening Platform |
Industry standard HTS screening facilities and a 500,000 compound library to screen any novel drug targets for free. |
link | Free | |
eTRIKS |
Standards Starter Pack |
Procedures for dealing with data standards and standards stewardship. |
link | Free | |
eTOX | Human Outcomes Module |
Human Outcomes Module is a web service that allows the search of similar marketed drugs from a simple SMILES code and retrieves adverse events data associated to these drugs from three sources currently implemented: literature (PubMed), EURETOS and LAERTES. | link | Free | |
eTOX | eTOX library |
A chronological selection of recommended articles, a list of selected journals extracted from ISI Web of Knowledge with toxicology filtering, and finally, a section of interesting links, where all these resources are presented by alphabetic order and organized by categories. See Mol Inf 2013;32:24-35. |
link | Free | |
eTOX | LiMTox | The LiMTox system is a text mining approach that extracts associations between compounds and toxicological end points at various levels of granularity and evidence types. | link | Free | |
eTOX | Standardiser | The Standardiser is a tool designed to provide a simple way of standardising molecules as a prelude to e.g. molecular modelling exercises. | link | Free | |
eTOX | Collector | Collector is a tool that allows extracting from the Open PHACTS Discovery platform and the eTOX project series of compounds annotated with experimental data that can be used directly for building QSAR predictive models. Collector implements a flexible collection of filters for selecting the target, the biological data ranges and the physicochemical properties of the compounds. | link | Free | |
eTOX | eTOX verification | The verification of the models developed within the eTOX project comprises an assessment of (i) the quality of data used to build (and test) the model, (ii) whether the predictions generated by the model when executed in eTOXsys are consistent, and (iii) the completeness of the documentation accompanying the model. | link | Free | |
WEB-RADR |
Smartphone apps for adverse drug reactions |
UK, Netherlands and Croatian smartphone apps developed, enabling patients, caregivers, and healthcare professionals to report adverse drug reactions (ADRs) and receive up-to-date information and news alerts. |
link | Free | |
DDMoRe | Model Repository |
Open, publicly-available, free-to-use platform for models on the discovery, development and usage of drugs and spanning PK, PD and disease models as well as the range from empirical to systems pharmacology/biology models. The platform is indexed, fully searchable and supported by peer-review. |
link | Free | |
DDMoRe |
Interoperability Framework |
The Interoperability Framework is an integrated infrastructure to enable efficient exchange and integration of models across modelling languages, existing and new tools. |
link | Free | |
EMTRAIN | LifeTrain | LifeTrain is an open community working together to build a coherent framework for continuing professional development (CPD) in the European biomedical sciences. It brings together many excellent, but disparate, activities into a process towards establishing a focused and coherent framework for CPD in the biomedical sciences. This unique, pan-European collaborative approach provides the critical mass to make a major contribution to strengthen the skills and competencies of European biomedical professionals in a rapidly changing environment. | link | Free | |
iPiE | EcoDrug | The ECOdrug database contains information on the evolutionary conservation of human drug targets in over 600 eukaryotic species. The interface allows users to identify human drug targets to 1000+ legacy drugs and explore integrated orthologue predictions for the drug targets, transparently showing the confidence in the predictions both across methods and taxonomic groups. | Link | Free | |
iPiE |
iPiE-Sum |
The iPiE Summary Database Search (iPiE*Sum) provides high level summarised access to the properties, environmental fate characteristics and ecotoxicity of APIs which are collected during the course of the iPiE project from 2015 to 2018. iPiE*Sum is a web-based application conceived as a service to inform what studies have been performed for the approved pharmaceuticals. | Link | Free | |
iPiE |
iPiE Technical Model |
Human active pharmaceutical ingredients (APIs) are used in large quantities, and can partly end up in the environment because they are generally not completely broken down during passage through the human body and wastewater treatment plants (WWTPs). Pharmaceutical residues are mainly transported into the environment via the effluent of WWTPs. Although concentrations reported are generally low, adverse ecological effects caused by some pharmaceuticals are plausible considering their specific modes of action and high potency. | Link | Free | |
K4DD | KBbox: A Toolbox of Computational Methods for Studying the Kinetics of Molecular Binding |
Information about various computational methods for studying molecular binding kinetics, and the computational tools that employ them. KBbox is developed to be of use to researchers interested in applying these methods in their work. To help with this, KBbox provides an updated list of examples of published work, along with detailed tutorials to guide less experienced researchers. |
Link | Free | |
RADAR-CNS |
RADAR-base, a platform to support wearable device data |
RADAR-base is an open-source platform that aims to support scientific research with wearable device data. It allows study participants to share their health data with clinicians and researchers in a secure way. It enables study design and set up, active and passive remote data collection, secure data transmission via Wifi and/or Bluetooth and scalable solutions for data storage, management and access. |
Apache 2 open source license | ||
CHEM21 | CHEM21 Metrics Toolkit |
This unified metrics toolkit can be used to comprehensively evaluate the sustainability of chemical and bio-chemical reactions based on a series of key parameters. The rationale behind the creation of the toolkit and description of the methodologies adopted is available as an open access publication and the Toolkit itself is available in the form of a user friendly excel spreadsheet in the supplementary information of the publication. |
Free | ||
CHEM21 | CHEM21 Solvent Selection Guide |
This solvent selection guide differs from other available solvent ranking systems as it incorporates the assessment of bio-derived as well as classical solvents on a level playing field. The guide and associated methodology for its creation are provided in an open access publication. In addition, there is an associated Excel spreadsheet and online tool that will enable the user to rank a solvent not included in the list according to the guidelines outlined in the publication.
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Free | ||
COMBACTE-MAGNET | The Patient and Public Involvement Toolkit | Provides systematic and evidence-based guidance on how and when to involve the public in medicines development research, in particular antimicrobials. | link | Free | |
iABC |
Bronchiectasis patients registry |
EMBARC is a pan-European network committed to promoting clinical research and education in bronchiectasis, through sharing of protocols, research idea and expertise. Central to this project is the creation of the European Bronchiectasis Registry, a collaboration open to all investigators around Europe caring for patients with bronchiectasis. |
link | Free | |
iABC | Multiple breath washout online training |
The lung clearance index (LCI) is a lung function parameter derived from the multiple-breath washout (MBW) test. LCI is being explored as a novel exploratory endpoint of lung disease severity and response to inhaled antibiotic therapy in patients with Cystic Fibrosis and Bronchiectasis. This online tool provides training in the use of MBW equipment and the interpretation of results. |
link | Free | |
eTRANSAFE | FLAME |
A flexible framework supporting predictive modeling within the eTRANSAFE project. Easily develop machine-learning models, for example QSAR-like models, starting from annotated collections of chemical compounds stored in standard formats (i.e. SDFiles). Transfer new models into a production environment where they can be used by web services to predict the properties of new compounds. |
link | Free | |
ADAPT- SMART |
Infographics tool | Online tool capturing all outcomes of the project, e.g reports, discussion papers, workshop summaries related to tools and methodologies enabling implementation of medicines adaptive pathways to patients (MAPPs) in Europe. | link | Free | |
COMBACTE-NET |
White paper |
Recommendations for improving the design and analysis of clinical trials for antibacterials against multidrug-resistant organisms. | link | Free | |
COMBACTE-MAGNET |
EPI-Net platform |
Online platform that provides timely access to data on emergence and spread of antimicrobial resistance (AMR) in humans and animal sector and healthcare-associated infections (HAI). The platform connects various national and international European surveillance systems for infections and outbreaks due to antibiotic resistant bacteria by linking microbiologic and epidemiological data. |
link | Free | |
PRO-active |
Patient reported outcomes |
Two patient reported outcome (PRO) instruments to capture physical activity (PA) data in patients with chronic obstructive pulmonary disease (COPD) in clinical trial settings: 1) D-PPAC (for daily data collection with a recall period of 1 day); and 2) C-PPAC (recall period of 7 days, intended to collect PA data during specified clinical study visits). The tools have been qualified by the European Medicines Agency. |
Free | ||
DRIVE-AB | Report: 'Revitalizing the antibiotic pipeline' |
Report on research-based suggestions for driving antibiotic development while ensuring access and sustainable use. |
link | Free | |
DRIVE-AB | Report |
Report on quality indicators and quantity metrics of antibiotic use. |
link | Free | |
NEWMEDS | DupCheck | DupCheck is a web-based tool used globally to screen for duplicate patients in clinical trials across studies, sponsors and therapeutic areas. Duplicate enrollment harms both patients and studies. | link | Contract per study or via subscription | |
OrBiTo | In vitro dissolution test device | In vitro method that mimics gastro-intestinal mechanical forces and its impact on drug dissolution | link |
Commercially available |
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EHDEN |
Directory of certified data harmonisation service providers |
Directory of all EHDEN certified service providers to enable data partners to easily find the provider of their choice to help them with the harmonisation of their data to the OMOP CDM. Includes a high-level overview of the capabilities and experience of each service provider, as well as contact information and information on for example which working languages they feel comfortable with. The directory categorizes providers according to the services they offer, amongst which: Installation of OHDSI Software and Tools / Providing OHDSI Training / Creating and running OMOP CDM ETL / Mapping to OMOP Standardized vocabularies / Technical infrastructure Services. |
link | Free | |
EMIF | TASKA (EMIF Task Management) | TASKA is an innovative platform designed to streamline the creation of modular and easily extendable workflows to manage data extraction and handling general work processes. It is based on Software-as-a-Service approach, making it more versatile and easy to integrate by third party applications | Contact Prof. JL Oliveira, University of Aveiro - jlo [AT] ua.pt | Free | |
EMIF | Jerboa distributive network scripted research tool | The Jerboa software is developed at the Department of Medical Informatics, Erasmus MC to enable pharmaco-epidemiological studies in a so-called distributive network design, i.e. it runs de-identification, analysis and aggregation locally at each database site. This has the advantage that the local analyses are performed in a common way and are not subject to small differences in implementation by local statisticians. | link | Free | |
EMIF | OCTOPUS remote research environment | The OCTOPUS infrastructure is used as a prototype for the private remote research environment (PRRE) in WP12. It allows for secured file transfer from and to the data custodians and can be used to collaborate on the aggregated data generated by Jerboa, and other tools. Originally developed at Department of Medical Informatics, Erasmus MC, a cloud instance, 2.0 is now available via University of Aveiro. | Contact Prof. JL Oliveira, University of Aveiro - jlo [AT] ua.pt | Free | |
EMIF | EMI-AD Switchbox | Switchbox provides a single interface for cohort owners, data harmonisation via a variant of the OMOP Common Data Model, but multiple harmonised outputs for diverse AD projects. | Contact
M Van Speybroeck, Janssen Pharmaceutica - mvspeybr [AT] its.jnj.com - or PJ Visser, Maastricht University - pj.visser [AT] maastrichtuniversity.nl |
Free | |
EMIF | EMIF-AD Participant Selection Tool | The Participant Selection Tool allows researchers to get an overview of patient profiles in a given cohort, filtering on a set of predefined key characteristics. The tool has currently been built to provide this capability for AD cohort data sets. | Contact
M Van Speybroeck, Janssen Pharmaceutica - mvspeybr [AT] its.jnj.com - or PJ Visser, Maastricht University - pj.visser [AT] maastrichtuniversity.nl |
Free | |
EMIF | EMIF-AD Variable Selection Tool (VST) | VST provides the researcher with an overview of available variables (counts, not values), followed by data access request to the selected cohort owners. | Contact
M Van Speybroeck, Janssen Pharmaceutica - mvspeybr [AT] its.jnj.com - or PJ Visser, Maastricht University - pj.visser [AT] maastrichtuniversity.nl |
Free | |
COMBACTE-NET |
Sample Collection and Management Manual |
Manual to provide guidance through the sample collection and the different processing procedures that are to be performed within a clinical trial for pathogens detection. This serves as a template to facilitate development of clinical study-specific manuals. |
link |
Free |
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EBODAC | Handbook:
Community Engagement, Communications, and Technology for Clinical Trials in Outbreak Settings |
Online, open access training resource relevant for anybody who is interested in community engagement, communications and enabling technologies for clinical trials in outbreak settings. |
link | Free | |
DO-IT |
Harmonised Informed Consent Form (ICF) template to facilitate the secondary use of personal data |
Harmonised ICF template for clinical studies and further research. Covers all information required by the General Data Protection Regulation (GDPR) within a traditional (non-electronic) informed consent document to be signed by patients or healthy volunteers before participating in a clinical study. The ICF aims to address the processing of personal data for (a) the conduct of a clinical study within a drug development programme (Part 1) and (b) future scientific research on personal data and biosamples collected in clinical studies, i.e. research beyond of the original drug development programme. |
link | Free | |
DO-IT |
Toolkit for the identification, selection, and measurement of outcomes including in real-world settings |
The toolkit proposes six main stages to develop Core Outcome Sets, from scoping to dissemination, with a focus on stakeholder input across all stages to ensure a wide range of perspectives are taken into account. Whilst the toolkit highlights any existing best practice to developing COS, it importantly also presents a range of methodological options which BD4BO projects can consider depending on the scope of the work and resources available. |
link | Free | |
DO-IT |
Public webinar on outcomes standardisation |
Webinar to introduce Core Outcome Sets (COS) and their role in harmonising outcomes generated in real world settings. Presentation of a toolkit giving methodological and practical guidance on developing COS, including for use in real world settings. Explanations of experiences from the different BD4BO projects including, for example, on involving patient perspectives in the standardisation of outcomes |
link | Free | |
ROADMAP |
ROADMAP Alzheimer’s Disease data cube |
3D heat map assessment which allows the visualisation of the landscape on available Alzheimer’s disease data in Europe, together with their relevance for different stages of the disease. |
link |
Free |
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c4c | Toolkit of educational resources available for young patients and their families |
Living depository of information and materials to help patients and their families get started in patient and public involvement in the development of medicines e.g to help understanding what a clinical trial is, what happens in a clinical trial, the ethical and legal implications and the role that young patients can play in the development of clinical trials. |
link |
Free |
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EPAD | EPAD LCS (longitudinal cohort study) Research Access Process | The EPAD LCS Research Access Process (ERAP) is designed to give academic researchers and institutions from all over the world a way of accessing the data, samples and image data collected during EPAD's longitudinal cohort study on the prevention of Alzheimer's dementia. | link | Free | |
RESOLUTE | Solute Carrier Knowledgebase | The Knowledgebase brings together in one place high quality, reliable information on solute carriers (SLCs) from multiple publicly available sources. Data is connected and integrated, allowing SLC researchers to rapidly get an overview on the current knowledge on any human SLC transporter. | link | Free | |
DIRECT | Liver fat prediction tool |
Early diagnosis of non-alcoholic fatty liver disease (NAFLD) can help prevent irreversible damage to the liver and ultimately hepatocellular carcinomas. The liver fat prediction models are for early-stage diagnosis of fatty liver, which may have utility for clinical diagnosis and research investigation alike. |
link | Free | |
MACUSTAR |
Clinical study protocol and related procedure manuals |
Clinical study protocol for a low-interventional study in intermediate age-related macular degeneration developing novel clinical endpoints for interventional clinical trials with a regulatory and patient access intention. Accompanying procedure manuals for
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link |
Free – to get the manuals interested parties can send a statement of intended use, including the goals and objectives of the project and intended audience to mail@macustar.eu |
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BioVacSafe | Biomarkers of vaccine immunosafety |
BioProject Umbrella Project entry (Accession: PRJNA515032 ID: 515032) for a digital archive of gene expression, RNA sequence, clinical and preclinical animal model data, demographics, treatment allocations, vital signs and adverse events metadata from human and murine immunisation with a range of live, subunit and adjuvanted vaccines and positive controls. |
link | Free | |
NGN-PET | NIPPY (Neuro-Immune interactions in the Periphery) webtool | A webtool for researchers working in the space of neuro-immune interactions in the peripheral nervous system. This webpage brings together cell-type specific RNA-seq data from cell types that are relevant in peripheral neuroimmune interactions. The project produced and gathered other people's data on peripheral neurons, Schwann cells, macrophages and T cells in naive and nerve injury states.
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Free | ||
BioVacSafe | BioVacSafe biobank | A biobank of biological samples (serum, plasma, RNA, cells) taken at frequent time points after immunisation of humans and mice with a range of live, subunit and adjuvanted vaccines and positive controls. | link | Applications for access to BIOVACSAFE samples for approved use under the terms of sample deposition should be made to the contacts listed on the website. | |
NGN-PET | Phenotypic in vitro assay for neurotoxicity | Neuronal cells cultures (primary rodent DRG and hiPSC derived sensory neurons) have been optimised in miniaturised formats (384 well-plates). A pipeline analysis for neurite outgrowth and mitochondrial morphology evaluation upon drug treatment was validated. The neurotoxic model was set by exposing the cells to the antineoplastic compound Vincristine. Results showed Vincristine toxicity measurable in terms of reduction of neurites network and alteration of mitochondrial morphology. The assay window is robust, reproducible, and suitable for compound testing. | Commercial / research agreement | ||
NGN-PET | Generation of iPSC reporter cell lines | Using CRISPR/Cas9 genome editing technology, hiPSCs were genetically modified to express fluorescent proteins as 1) specific lineage markers (mCherry; eGFP) or 2) genetically encoded sensor for intracellular Calcium transients (GCaMP6f). In the first case the cDNA encoding a fluorescent protein was inserted in frame with TRPV1, a marker of sensory neuron; in the second case the cDNA encoding GCaMP6f was inserted in a genome safe harbor. Procedures have been validated by positive results and can be applied on request to specific cases. | Commercial / research agreement | ||
NGN-PET |
hiPSC derived functional and phenotypic assays for compound screening |
hiPSC derived neuronal cultures and co-cultures, with non-neuronal cells, were adapted to FLIPRTETRA and Operetta platforms and are suitable to perform compound testing/screening in different assays. | Commercial / research agreement | ||
COMBACTE-MAGNET | AMR Travel Tool | An online tool that allows healthcare professionals and the public to assess the risk of international travellers acquiring (and spreading) antimicrobial-resistant bacteria. | Link | Free | |
NEURONET | Knowledge Base | A one-stop-shop with information on the outputs of around 20 IMI neurodegeneration projects, including publications, reports, and assets such as genetic datasets, clinical cohorts & data platforms | Link | Free | |
AETIONOMY | NeuroMMSig server |
A knowledge base representing essential pathophysiology mechanisms of neurodegenerative diseases. Together with dedicated algorithms, this knowledge base forms the basis for a “mechanism-enrichment server” that supports the mechanistic interpretation of multiscale, multimodal clinical data. Information from the Neuronet Knowledge Base |
Link | Free | |
EQIPD | Online toolbox |
An online, wiki-based platform that collects and disseminates information (guidelines, tools, literature, web links, etc.) related to various aspects of research rigour. Information from the Neuronet Knowledge Base |
Link | Free | |
EQIPD | Training platform |
An online educational platform providing education and training in the principles and application of quality and rigour in preclinical studies, where there are currently a number of e-learning modules available.
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Link | Free | |
CONCEPTION | Glossary |
ConcepTION's glossary provides definition of terms related to medicinal product information, medicines development and research into the safety of medicines during pregnancy and breastfeeding This glossary is shared with other European projects, who are collaborating to help grow a useful resource for all. The project glossary editors can review each other's entries and bring them in to their own project glossary if they wish. It has been developed and is hosted by the European Institute for Innovation through Health Data, in partnership with RAMIT. |
Link | Free | |
FAIRplus |
FAIR Cookbook |
Created by researchers and data managers professionals, the FAIR Cookbook is an online resource for the Life Sciences with recipes that help you to make and keep data Findable, Accessible, Interoperable and Reusable (FAIR). The FAIR Cookbook provides recipes for you to learn: how to FAIRify datasets, the levels and indicators of FAIRness, the maturity model, the technologies, the tools and the standards available, as well as the skills required, and the challenges, to achieve and improve FAIRness. The FAIR Cookbook guides researchers and data managers in their FAIRification journey; and also provides policy makers and trainers with practical examples to recommend in their guidance and use in their educational material. |
Link |
All content of the FAIR Cookbook is licensed under the Creative Commons Attribution 4.0 International (CC BY 4.0) license. |
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ITCC-P4 |
Target Actionability Review (TAR) |
Methodology for Target Actionability Reviews (TARs) to assess the potential actionability of a target gene/pathway to identify mechanism-of-action-based matches between targeted anti-cancer drugs and specific paediatric cancer subtypes. TARs including study scores, key data summaries and source information available through the R2 Genomics Analysis and Visualization Platform. |
Free | ||
PARADIGM | Patient Engagement Toolbox | The toolbox centralises all PARADIGM's recommendations and tools as well as relevant background information to make patient engagement in medicines development easier for all | Link | Free | |
SPRINTT |
SRINTT Physical exercise booklet and SPRINTT nutrition workbook– Nutritional recommendations for active and healthy aging |
These booklets provide most important recommendations to preserve physical function in old age. |
Free |